Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death

DS Simpson; H Anderton; J Yousef; V Vaibhav; SA Cobbold; E Bandala-Sanchez; AJ Kueh; LF Dagley; MJ Herold; J Silke; JE Vince; R Feltham

Journal article

Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death

DS Simpson, H Anderton, J Yousef, V Vaibhav, SA Cobbold, E Bandala-Sanchez, AJ Kueh, LF Dagley, MJ Herold, J Silke, JE Vince, R Feltham

Pnas Nexus | OXFORD UNIV PRESS | Published : 2024

DOI: 10.1093/pnasnexus/pgad438

Abstract

Skin inflammation is a complex process implicated in various dermatological disorders. The chronic proliferative dermatitis (cpd) phenotype driven by the cpd mutation (cpdm) in the Sharpin gene is characterized by dermal inflammation and epidermal abnormalities. Tumour necrosis factor (TNF) and caspase-8-driven cell death causes the pathogenesis of Sharpincpdm mice; however, the role of mind bomb 2 (MIB2), a pro-survival E3 ubiquitin ligase involved in TNF signaling, in skin inflammation remains unknown. Here, we demonstrate that MIB2 antagonizes inflammatory dermatitis in the context of the cpd mutation. Surprisingly, the role of MIB2 in limiting skin inflammation is independent of its know..

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University of Melbourne Researchers

Jumana Yousef Author

Vineet Vaibhav Author

Simon Cobbold Author

Maria Bandala Sanchez Author

Related Projects (1)

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Grants

Awarded by Australian Government

Funding Acknowledgements

The authors thank Rhiannan Crawley, Sophia Russo, Natasha Blasch, Lauren Wilkins, Tom Kitson, Roxanne Monaghan, Hayley Marks, and Dannielle Cooper for their excellent animal husbandry and scoring of mice. The analysis of Mib2-/- and Mib2KI/KI mice used in this study was supported by the Phenomics Australia and the Australian Government through the National Collaborative Research Infrastructure Strategy (NCRIS) program. The authors acknowledge the facilities, and the scientific and technical assistance of Phenomics Australia, which is supported by the Australian Government through the National Collaborative Research Infrastructure Strategy (NCRIS) program.